Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle

OBJECTIVE: Branched-chain amino acids, such as leucine and glucose, stimulate protein synthesis and increase the phosphorylation and activity of the mammalian target of rapamycin (mTOR) and its downstream target p70S6 kinase (p70S6K). We examined in skeletal muscle whether the effects of leucine and...

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Detalles Bibliográficos
Autores principales: Saha, Asish K., Xu, X. Julia, Lawson, Ebony, Deoliveira, Rosangela, Brandon, Amanda E., Kraegen, Edward W., Ruderman, Neil B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279521/
https://www.ncbi.nlm.nih.gov/pubmed/20682696
http://dx.doi.org/10.2337/db09-1870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279521/
https://www.ncbi.nlm.nih.gov/pubmed/20682696
http://dx.doi.org/10.2337/db09-1870

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