Cargando…

Angiotensin I–Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice

OBJECTIVE: Several clinical studies have shown the benefits of renin-angiotensin system (RAS) blockade in the development of diabetes, and a local RAS has been identified in pancreatic islets. Angiotensin I–converting enzyme (ACE)2, a new component of the RAS, has been identified in the pancreas, bu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bindom, Sharell M., Hans, Chetan P., Xia, Huijing, Boulares, A. Hamid, Lazartigues, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279528/ https://www.ncbi.nlm.nih.gov/pubmed/20660625 http://dx.doi.org/10.2337/db09-0782

Ejemplares similares

The sweeter side of ACE2: Physiological evidence for a role in diabetes
por: Bindom, Sharell M., et al.
Publicado: (2009)

Angiotensin‐converting enzyme 2 in the brain: properties and future directions
por: Xia, Huijing, et al.
Publicado: (2008)

Angiotensin-Converting Enzyme 2: Central Regulator for Cardiovascular Function
por: Xia, Huijing, et al.
Publicado: (2010)

ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function
por: Xia, Huijing, et al.
Publicado: (2011)

Neprilysin Is Required for Angiotensin-(1–7)’s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1–2)
por: Brar, Gurkirat S., et al.
Publicado: (2017)

Angiotensin-Converting Enzyme 2 Over-Expression in the Central Nervous System Reduces Angiotensin-II-Mediated Cardiac Hypertrophy
por: Feng, Yumei, et al.
Publicado: (2012)

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients
por: Fløyel, Tina, et al.
Publicado: (2021)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Inhibition of Ca(2+)-Independent Phospholipase A(2)β (iPLA(2)β) Ameliorates Islet Infiltration and Incidence of Diabetes in NOD Mice
por: Bone, Robert N., et al.
Publicado: (2015)

Three key proteases – angiotensin-I-converting enzyme (ACE), ACE2 and renin – within and beyond the renin-angiotensin system
por: Guang, Cuie, et al.
Publicado: (2012)

Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure
por: Patel, Vaibhav B., et al.
Publicado: (2012)

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling
por: Clarke, Nicola E., et al.
Publicado: (2012)

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19
por: Ni, Wentao, et al.
Publicado: (2020)

Characterization of Angiotensin Converting Enzyme-2 (ACE2) in Human Urine
por: Lew, Rebecca A., et al.
Publicado: (2006)

Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants
por: Daskaya-Dikmen, Ceren, et al.
Publicado: (2017)

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome
por: Gómez, Juan, et al.
Publicado: (2020)

Covid-19 and the angiotensin-converting enzyme (ACE2): Areas for research
por: Omar, Michael Brandon
Publicado: (2020)

Higher Angiotensin I Converting Enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease
por: Louise, Reveret, et al.
Publicado: (2023)

Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer’s disease brain
por: Ding, Qiyue, et al.
Publicado: (2020)

Measurement of Angiotensin Converting Enzyme 2 Activity in Biological Fluid (ACE2)
por: Xiao, Fengxia, et al.
Publicado: (2017)

Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
por: Abdul-Hafez, Amal, et al.
Publicado: (2021)

Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19
por: Kuba, Keiji, et al.
Publicado: (2021)

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2
por: Clayton, Daniel, et al.
Publicado: (2015)

Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2
por: Vio, Carlos P., et al.
Publicado: (2020)

The Race for ACE: Targeting Angiotensin-Converting Enzymes (ACE) in SARS-CoV-2 Infection
por: Schieffer, Elisabeth, et al.
Publicado: (2022)

Forkhead Box Transcription Factors of the FOXA Class Are Required for Basal Transcription of Angiotensin-Converting Enzyme 2
por: Pedersen, Kim Brint, et al.
Publicado: (2017)

Mechanisms of Control of the Free Ca(2+) Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells: Interplay With Cell Metabolism and [Ca(2+)](c) and Role of SERCA2b and SERCA3
por: Ravier, Magalie A., et al.
Publicado: (2011)

Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age
por: Tamanna, Sonia, et al.
Publicado: (2020)

Angiotensin Converting Enzyme 2 (ACE2) Expression in the Aged Brain and Visual System
por: Hill, James M., et al.
Publicado: (2021)

Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation
por: Turner, Anthony J., et al.
Publicado: (2022)

Exendin-4 Stimulation of Cyclin A2 in β-Cell Proliferation
por: Song, Woo-Jin, et al.
Publicado: (2008)

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca(2+)-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells
por: Demozay, Damien, et al.
Publicado: (2011)

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
por: Hisanaga, Etsuko, et al.
Publicado: (2009)

Islet inflammation is associated with pancreatic fatty infiltration and hyperglycemia in type 2 diabetes
por: Horii, Tomomi, et al.
Publicado: (2020)

The carboxypeptidase angiotensin converting enzyme (ACE) shapes the MHC class I peptide repertoire
por: Shen, Xiao Z., et al.
Publicado: (2011)

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)
por: Yates, Christopher J., et al.
Publicado: (2014)

Conformational Fingerprinting Using Monoclonal Antibodies (on the Example of Angiotensin I-Converting Enzyme-ACE)
por: Danilov, S. M.
Publicado: (2017)

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced K(ATP) Channel Activity
por: Gregg, Trillian, et al.
Publicado: (2016)

Bcl-2 and Bcl-x(L) Suppress Glucose Signaling in Pancreatic β-Cells
por: Luciani, Dan S., et al.
Publicado: (2013)

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet
por: Syed, Ismail, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_d3fma2l64l6v33n0siadn8hcdq