Cargando…

Insulin Transactivator MafA Regulates Intrathymic Expression of Insulin and Affects Susceptibility to Type 1 Diabetes

OBJECTIVE: Tissue-specific self-antigens are ectopically expressed within the thymus and play an important role in the induction of central tolerance. Insulin is expressed in both pancreatic islets and the thymus and is considered to be the primary antigen for type 1 diabetes. Here, we report the ro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noso, Shinsuke, Kataoka, Kohsuke, Kawabata, Yumiko, Babaya, Naru, Hiromine, Yoshihisa, Yamaji, Kaori, Fujisawa, Tomomi, Aramata, Shinsaku, Kudo, Takashi, Takahashi, Satoru, Ikegami, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279543/ https://www.ncbi.nlm.nih.gov/pubmed/20682694 http://dx.doi.org/10.2337/db10-0476

Ejemplares similares

Prolonged hyperinsulinemia after subcutaneous injection of 2400 U regular insulin in a suicide attempt: Time course of serum insulin with frequent measurements
por: Hiromine, Yoshihisa, et al.
Publicado: (2012)

Insulin deficiency with and without glucagon: A comparative study between total pancreatectomy and type 1 diabetes
por: Niwano, Fumimaru, et al.
Publicado: (2018)

Early-Onset Diabetes Mellitus in a Patient With a Chromosome 13q34qter Microdeletion Including IRS2
por: Babaya, Naru, et al.
Publicado: (2018)

Genetic dissection of susceptibility genes for diabetes and related phenotypes on mouse chromosome 14 by means of congenic strains
por: Babaya, Naru, et al.
Publicado: (2014)

Verification That Mouse Chromosome 14 Is Responsible for Susceptibility to Streptozotocin in NSY Mice
por: Babaya, Naru, et al.
Publicado: (2018)

Flash glucose monitoring in type 1 diabetes: A comparison with self‐monitoring blood glucose
por: Babaya, Naru, et al.
Publicado: (2020)

Relationship of continuous glucose monitoring-related metrics with HbA1c and residual β-cell function in Japanese patients with type 1 diabetes
por: Babaya, Naru, et al.
Publicado: (2021)

Dose Effect and Mode of Inheritance of Diabetogenic Gene on Mouse Chromosome 11
por: Babaya, Naru, et al.
Publicado: (2013)

Novel loci for hyperglycemia identified by QTL mapping of longitudinal phenotypes and congenic analysis
por: Babaya, Naru, et al.
Publicado: (2023)

Glucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy
por: Niwano, Fumimaru, et al.
Publicado: (2021)

Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention
por: Ikegami, Hiroshi, et al.
Publicado: (2011)

Insulin‐dependent diabetes mellitus in older adults: Current status and future prospects
por: Ikegami, Hiroshi, et al.
Publicado: (2022)

Glycemic Excursion and Insulin Action Revealed in a Rare Case of Type 1 Diabetes Complicated with Short Bowel Syndrome
por: Hiromine, Yoshihisa, et al.
Publicado: (2022)

Effects of dosage and dosing frequency on the efficacy and safety of high‐dose metformin in Japanese patients with type 2 diabetes mellitus
por: Kanto, Kousei, et al.
Publicado: (2017)

Clinical and genetic determinants of urinary glucose excretion in patients with diabetes mellitus
por: Monobe, Keisuke, et al.
Publicado: (2020)

Metabolic signatures of β‐cell destruction in type 1 diabetes
por: Noso, Shinsuke, et al.
Publicado: (2022)

Mixed Corticomedullary Tumor Accompanied by Unilateral Aldosterone-Producing Adrenocortical Micronodules: A Case Report
por: Yoshida, Sawa, et al.
Publicado: (2021)

A Rare Case of Adrenal Cysts Associated With Bilateral Incidentalomas and Diffuse Hyperplasia of the Zona Glomerulosa
por: Babaya, Naru, et al.
Publicado: (2020)

Loss of MafA and MafB expression promotes islet inflammation
por: Singh, Tania, et al.
Publicado: (2019)

Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism
por: Babaya, Naru, et al.
Publicado: (2017)

MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition
por: Xiafukaiti, Gulibaikelamu, et al.
Publicado: (2019)

MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulin(+) cells
por: Chiou, Shih-Hwa, et al.
Publicado: (2011)

MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes
por: Ganic, Elvira, et al.
Publicado: (2016)

MafB Maintains β-Cell Identity under MafA-Deficient Conditions
por: Deng, Zhaobin, et al.
Publicado: (2022)

Three-Year Observation of Glucose Metabolism After Pancreaticoduodenectomy: A Single-Center Prospective Study in Japan
por: Niwano, Fumimaru, et al.
Publicado: (2022)

TAT-Mediated Transduction of MafA Protein In Utero Results in Enhanced Pancreatic Insulin Expression and Changes in Islet Morphology
por: Vargas, Nancy, et al.
Publicado: (2011)

Generation of Insulin-Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD
por: Lee, So-Hyun, et al.
Publicado: (2017)

Specific reprogramming of alpha cells to insulin-producing cells by short glucagon promoter-driven Pdx1 and MafA
por: Guo, Ping, et al.
Publicado: (2023)

β‐Cell failure in diabetes: Common susceptibility and mechanisms shared between type 1 and type 2 diabetes
por: Ikegami, Hiroshi, et al.
Publicado: (2021)

MafA Is Required for Postnatal Proliferation of Pancreatic β-Cells
por: Eto, Koki, et al.
Publicado: (2014)

Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells
por: Arcidiacono, Biagio, et al.
Publicado: (2015)

Oncocytic Adrenocortical Carcinoma With Low (18)F-FDG Uptake and the Absence of Glucose Transporter 1 Expression
por: Babaya, Naru, et al.
Publicado: (2021)

Associations between genetic loci related to lean mass and body composition in type 2 diabetes
por: Minohara, Tatsuro, et al.
Publicado: (2021)

MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
por: Artner, Isabella, et al.
Publicado: (2010)

Correction: MafA Is Required for Postnatal Proliferation of Pancreatic β-Cells
Publicado: (2014)

MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets
por: Singh, Tania, et al.
Publicado: (2018)

Type 2 diabetes susceptibility genes on mouse chromosome 11 under high sucrose environment
por: Kobayashi, Misato, et al.
Publicado: (2020)

MafA Overexpression: A New Efficient Protocol for In Vitro Differentiation of Adipose-Derived Mesenchymal Stem Cells into Functional Insulin-Producing Cells
por: Dayer, Dian, et al.
Publicado: (2019)

An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition
por: Deng, Zhaobin, et al.
Publicado: (2020)

MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms
por: Liang, Jiani, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fk8t70bd8pfemgb3v6vpiq93pk