Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

OBJECTIVE: The contribution of mitochondrial dysfunction to skeletal muscle insulin resistance remains elusive. Comparative proteomics are being applied to generate new hypotheses in human biology and were applied here to isolated mitochondria to identify novel changes in mitochondrial protein abund...

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Detalles Bibliográficos
Autores principales: Lefort, Natalie, Glancy, Brian, Bowen, Benjamin, Willis, Wayne T., Bailowitz, Zachary, De Filippis, Elena A., Brophy, Colleen, Meyer, Christian, Højlund, Kurt, Yi, Zhengping, Mandarino, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279558/
https://www.ncbi.nlm.nih.gov/pubmed/20682693
http://dx.doi.org/10.2337/db10-0174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279558/
https://www.ncbi.nlm.nih.gov/pubmed/20682693
http://dx.doi.org/10.2337/db10-0174

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