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Winnowing DNA for Rare Sequences: Highly Specific Sequence and Methylation Based Enrichment
Rare mutations in cell populations are known to be hallmarks of many diseases and cancers. Similarly, differential DNA methylation patterns arise in rare cell populations with diagnostic potential such as fetal cells circulating in maternal blood. Unfortunately, the frequency of alleles with diagnos...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280224/ https://www.ncbi.nlm.nih.gov/pubmed/22355378 http://dx.doi.org/10.1371/journal.pone.0031597 |