Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24

BACKGROUND: The proteolytic maturation of the nuclear protein lamin A by the zinc metalloprotease ZMPSTE24 is critical for human health. The lamin A precursor, prelamin A, undergoes a multi-step maturation process that includes CAAX processing (farnesylation, proteolysis and carboxylmethylation of t...

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Detalles Bibliográficos
Autores principales: Barrowman, Jemima, Hamblet, Corinne, Kane, Megan S., Michaelis, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280227/
https://www.ncbi.nlm.nih.gov/pubmed/22355414
http://dx.doi.org/10.1371/journal.pone.0032120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280227/
https://www.ncbi.nlm.nih.gov/pubmed/22355414
http://dx.doi.org/10.1371/journal.pone.0032120

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