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Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances
BACKGROUND: Driven essentially by random genetic drift, subfunctionalization has been identified as a possible non-adaptive mechanism for the retention of duplicate genes in small-population species, where widespread deleterious mutations are likely to cause complementary loss of subfunctions across...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280233/ https://www.ncbi.nlm.nih.gov/pubmed/22168623 http://dx.doi.org/10.1186/1471-2164-12-604 |