Sphingosine Kinase 1 Mediation of Expression of the Anaphylatoxin Receptor C5L2 Dampens the Inflammatory Response to Endotoxin

The complement anaphylatoxin C5a has a pathogenetic role in endotoxin-induced lung inflammatory injury by regulating phagocytic cell migration and activation. Endotoxin and C5a activate the enzyme sphingosine kinase (Sphk) 1 to generate the signaling lipid sphingosine-1-phosphate (S1P), a critical r...

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Detalles Bibliográficos
Autores principales: Bachmaier, Kurt, Guzman, Edgar, Kawamura, Takeshi, Gao, Xiaopei, Malik, Asrar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280265/
https://www.ncbi.nlm.nih.gov/pubmed/22355325
http://dx.doi.org/10.1371/journal.pone.0030742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280265/
https://www.ncbi.nlm.nih.gov/pubmed/22355325
http://dx.doi.org/10.1371/journal.pone.0030742

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