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Identification of Stk25 as a Genetic Modifier of Tau Phosphorylation in Dab1-Mutant Mice
Hyperphosphorylation of the microtubule binding protein Tau is a feature of a number of neurodegenerative diseases, including Alzheimer's disease. Tau is hyperphosphorylated in the hippocampus of dab1-null mice in a strain-dependent manner; however, it has not been clear if the Tau phosphorylat...
Autores principales: | Matsuki, Tohru, Zaka, Mariam, Guerreiro, Rita, van der Brug, Marcel P., Cooper, Jonathan A., Cookson, Mark R., Hardy, John A., Howell, Brian W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280280/ https://www.ncbi.nlm.nih.gov/pubmed/22355340 http://dx.doi.org/10.1371/journal.pone.0031152 |
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