GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity. Initial data indicates that an intact fu...

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Detalles Bibliográficos
Autores principales: Stafa, Klodjan, Trancikova, Alzbeta, Webber, Philip J., Glauser, Liliane, West, Andrew B., Moore, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280333/
https://www.ncbi.nlm.nih.gov/pubmed/22363216
http://dx.doi.org/10.1371/journal.pgen.1002526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280333/
https://www.ncbi.nlm.nih.gov/pubmed/22363216
http://dx.doi.org/10.1371/journal.pgen.1002526

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