Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

Pregnane X receptor (PXR) has been reported to regulate the expression of drug-metabolizing enzymes, such as the cytochrome P450 3A (CYP3A) family and transporters, such as multiple drug resistance 1 (MDR1). Fucoxanthin, the major carotenoid in brown sea algae, is a putative chemopreventive agent. I...

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Detalles Bibliográficos
Autores principales: Liu, Cheng-Ling, Lim, Yun-Ping, Hu, Miao-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280533/
https://www.ncbi.nlm.nih.gov/pubmed/22363234
http://dx.doi.org/10.3390/md10010242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280533/
https://www.ncbi.nlm.nih.gov/pubmed/22363234
http://dx.doi.org/10.3390/md10010242

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