The Mechanism of Substrate Inhibition in Human Indoleamine 2,3-Dioxygenase

[Image: see text] Indoleamine 2,3-dioxygenase catalyzes the O(2)-dependent oxidation of l-tryptophan (l-Trp) to N-formylkynurenine (NFK) as part of the kynurenine pathway. Inhibition of enzyme activity at high l-Trp concentrations was first noted more than 30 years ago, but the mechanism of inhibiti...

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Detalles Bibliográficos
Autores principales: Efimov, Igor, Basran, Jaswir, Sun, Xiao, Chauhan, Nishma, Chapman, Stephen K., Mowat, Christopher G., Raven, Emma Lloyd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280726/
https://www.ncbi.nlm.nih.gov/pubmed/22299628
http://dx.doi.org/10.1021/ja208694g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280726/
https://www.ncbi.nlm.nih.gov/pubmed/22299628
http://dx.doi.org/10.1021/ja208694g

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