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The Mechanism of Substrate Inhibition in Human Indoleamine 2,3-Dioxygenase
[Image: see text] Indoleamine 2,3-dioxygenase catalyzes the O(2)-dependent oxidation of l-tryptophan (l-Trp) to N-formylkynurenine (NFK) as part of the kynurenine pathway. Inhibition of enzyme activity at high l-Trp concentrations was first noted more than 30 years ago, but the mechanism of inhibiti...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280726/ https://www.ncbi.nlm.nih.gov/pubmed/22299628 http://dx.doi.org/10.1021/ja208694g |