FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

Somatic rearrangement of immunoglobulin (Ig) genes is a key step during B cell development. Using pro–B cells lacking the phosphatase Pten (phosphatase and tensin homolog), which negatively regulates phosphoinositide-3-kinase (PI3K) signaling, we show that PI3K signaling inhibits Ig gene rearrangeme...

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Detalles Bibliográficos
Autores principales: Alkhatib, Alabbas, Werner, Markus, Hug, Eva, Herzog, Sebastian, Eschbach, Cathrin, Faraidun, Hemin, Köhler, Fabian, Wossning, Thomas, Jumaa, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280865/
https://www.ncbi.nlm.nih.gov/pubmed/22291095
http://dx.doi.org/10.1084/jem.20110216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280865/
https://www.ncbi.nlm.nih.gov/pubmed/22291095
http://dx.doi.org/10.1084/jem.20110216

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