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FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

Somatic rearrangement of immunoglobulin (Ig) genes is a key step during B cell development. Using pro–B cells lacking the phosphatase Pten (phosphatase and tensin homolog), which negatively regulates phosphoinositide-3-kinase (PI3K) signaling, we show that PI3K signaling inhibits Ig gene rearrangeme...

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Detalles Bibliográficos
Autores principales:	Alkhatib, Alabbas, Werner, Markus, Hug, Eva, Herzog, Sebastian, Eschbach, Cathrin, Faraidun, Hemin, Köhler, Fabian, Wossning, Thomas, Jumaa, Hassan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280865/ https://www.ncbi.nlm.nih.gov/pubmed/22291095 http://dx.doi.org/10.1084/jem.20110216

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