IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

The mammalian stress sensor IRE1α plays a central role in the unfolded protein, or endoplasmic reticulum (ER), stress response by activating its downstream transcription factor XBP1 via an unconventional splicing mechanism. IRE1α can also induce the degradation of a subset of mRNAs in a process term...

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Detalles Bibliográficos
Autores principales: Hur, Kyu Yeon, So, Jae-Seon, Ruda, Vera, Frank-Kamenetsky, Maria, Fitzgerald, Kevin, Koteliansky, Victor, Iwawaki, Takao, Glimcher, Laurie H., Lee, Ann-Hwee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280871/
https://www.ncbi.nlm.nih.gov/pubmed/22291093
http://dx.doi.org/10.1084/jem.20111298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280871/
https://www.ncbi.nlm.nih.gov/pubmed/22291093
http://dx.doi.org/10.1084/jem.20111298

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