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Tailoring inputs to achieve maximal neuronal firing

We consider the constrained optimization of excitatory synaptic input patterns to maximize spike generation in leaky integrate-and-fire (LIF) and theta model neurons. In the case of discrete input kicks with a fixed total magnitude, optimal input timings and strengths are identified for each model u...

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Detalles Bibliográficos
Autores principales: Wang, Jiaoyan, Costello, Willie, Rubin, Jonathan E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280888/
https://www.ncbi.nlm.nih.gov/pubmed/22656323
http://dx.doi.org/10.1186/2190-8567-1-3