The Role of Conserved Waters in Conformational Transitions of Q61H K-ras

To investigate the stability and functional role of long-residence water molecules in the Q61H variant of the signaling protein K-ras, we analyzed all available Ras crystal structures and conformers derived from a series of independent explicit solvent molecular dynamics (MD) simulations totaling 1....

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Detalles Bibliográficos
Autores principales: Prakash, Priyanka, Sayyed-Ahmad, Abdallah, Gorfe, Alemayehu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280954/
https://www.ncbi.nlm.nih.gov/pubmed/22359497
http://dx.doi.org/10.1371/journal.pcbi.1002394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280954/
https://www.ncbi.nlm.nih.gov/pubmed/22359497
http://dx.doi.org/10.1371/journal.pcbi.1002394

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