Nondisjunction of a Single Chromosome Leads to Breakage and Activation of DNA Damage Checkpoint in G2

The resolution of chromosomes during anaphase is a key step in mitosis. Failure to disjoin chromatids compromises the fidelity of chromosome inheritance and generates aneuploidy and chromosome rearrangements, conditions linked to cancer development. Inactivation of topoisomerase II, condensin, or se...

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Detalles Bibliográficos
Autores principales: Quevedo, Oliver, García-Luis, Jonay, Matos-Perdomo, Emiliano, Aragón, Luis, Machín, Félix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280967/
https://www.ncbi.nlm.nih.gov/pubmed/22363215
http://dx.doi.org/10.1371/journal.pgen.1002509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280967/
https://www.ncbi.nlm.nih.gov/pubmed/22363215
http://dx.doi.org/10.1371/journal.pgen.1002509

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