The S4–S5 Linker Acts as a Signal Integrator for hERG K(+) Channel Activation and Deactivation Gating

Human ether-à-go-go-related gene (hERG) K(+) channels have unusual gating kinetics. Characterised by slow activation/deactivation but rapid inactivation/recovery from inactivation, the unique gating kinetics underlie the central role hERG channels play in cardiac repolarisation. The slow activation...

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Detalles Bibliográficos
Autores principales: Ng, Chai Ann, Perry, Matthew D., Tan, Peter S., Hill, Adam P., Kuchel, Philip W., Vandenberg, Jamie I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280985/
https://www.ncbi.nlm.nih.gov/pubmed/22359612
http://dx.doi.org/10.1371/journal.pone.0031640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280985/
https://www.ncbi.nlm.nih.gov/pubmed/22359612
http://dx.doi.org/10.1371/journal.pone.0031640

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