Cargando…

The S4–S5 Linker Acts as a Signal Integrator for hERG K(+) Channel Activation and Deactivation Gating

Human ether-à-go-go-related gene (hERG) K(+) channels have unusual gating kinetics. Characterised by slow activation/deactivation but rapid inactivation/recovery from inactivation, the unique gating kinetics underlie the central role hERG channels play in cardiac repolarisation. The slow activation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ng, Chai Ann, Perry, Matthew D., Tan, Peter S., Hill, Adam P., Kuchel, Philip W., Vandenberg, Jamie I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280985/ https://www.ncbi.nlm.nih.gov/pubmed/22359612 http://dx.doi.org/10.1371/journal.pone.0031640

Ejemplares similares

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation
por: Ng, Chai Ann, et al.
Publicado: (2011)

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels
por: Tan, Peter S., et al.
Publicado: (2012)

Modulation of hERG K(+) Channel Deactivation by Voltage Sensor Relaxation
por: Shi, Yu Patrick, et al.
Publicado: (2020)

Saxitoxin Is a Gating Modifier of hERG K(+) Channels
por: Wang, Jixin, et al.
Publicado: (2003)

The N-linker region of hERG1a upregulates hERG1b potassium channels
por: Johnson, Ashley A., et al.
Publicado: (2022)

Voltage-Dependent Gating of hERG Potassium Channels
por: Cheng, Yen May, et al.
Publicado: (2012)

Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels
por: Gianulis, Elena C., et al.
Publicado: (2013)

Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation
por: Shi, Yu Patrick, et al.
Publicado: (2019)

Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel
por: Costa, Flavio, et al.
Publicado: (2022)

Gating Charges in the Activation and Inactivation Processes of the hERG Channel
por: Zhang, Mei, et al.
Publicado: (2004)

Modification of hERG1 channel gating by Cd(2+)
por: Abbruzzese, Jennifer, et al.
Publicado: (2010)

Dynamic Control of Deactivation Gating by a Soluble Amino-Terminal Domain in HERG K(+) Channels
por: Wang, Jinling, et al.
Publicado: (2000)

Negative Charges in the Transmembrane Domains of the HERG K Channel Are Involved in the Activation- and Deactivation-gating Processes
por: Liu, Jie, et al.
Publicado: (2003)

Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K(+) Channel Deactivation Gating from the Solution Structure of the EAG Domain
por: Muskett, Frederick W., et al.
Publicado: (2011)

Hysteretic hERG channel gating current recorded at physiological temperature
por: Jones, David K.
Publicado: (2022)

hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state
por: Malak, Olfat A., et al.
Publicado: (2017)

Stoichiometry of altered hERG1 channel gating by small molecule activators
por: Wu, Wei, et al.
Publicado: (2014)

Gating charge movement precedes ionic current activation in hERG channels
por: Goodchild, Samuel J, et al.
Publicado: (2014)

Up-Regulation of hERG K(+) Channels by B-RAF
por: Pakladok, Tatsiana, et al.
Publicado: (2014)

A k-nearest neighbor classification of hERG K(+) channel blockers
por: Chavan, Swapnil, et al.
Publicado: (2016)

hERG potassium channel gating is mediated by N- and C-terminal region interactions
por: Gustina, Ahleah S., et al.
Publicado: (2011)

Voltage Sensor Gating Charge Transfer in a hERG Potassium Channel Model
por: Colenso, Charlotte K., et al.
Publicado: (2014)

Novel roles for hERG K(+) channels in cell proliferation and apoptosis
por: Jehle, J, et al.
Publicado: (2011)

hERG K(+) Channels Promote Survival of Irradiated Leukemia Cells
por: Palme, Daniela, et al.
Publicado: (2020)

Molecular Determinants of Interactions between the N-Terminal Domain and the Transmembrane Core That Modulate hERG K(+) Channel Gating
por: Fernández-Trillo, Jorge, et al.
Publicado: (2011)

The eag domain regulates hERG channel inactivation gating via a direct interaction
por: Gustina, Ahleah S., et al.
Publicado: (2013)

Molecular Insights Into the Gating Kinetics of the Cardiac hERG Channel, Illuminated by Structure and Molecular Dynamics
por: Zequn, Zheng, et al.
Publicado: (2021)

A Molecular Switch Driving Inactivation in the Cardiac K(+) Channel hERG
por: Köpfer, David A., et al.
Publicado: (2012)

Drug trapping in hERG K(+) channels: (not) a matter of drug size?
por: Linder, Tobias, et al.
Publicado: (2016)

Computational Tool for Fast in silico Evaluation of hERG K(+) Channel Affinity
por: Chemi, Giulia, et al.
Publicado: (2017)

Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure
por: Zhang, Yihong, et al.
Publicado: (2020)

Na(+) Permeation and Block of hERG Potassium Channels
por: Gang, Hongying, et al.
Publicado: (2006)

Stereoselective Inhibition of the hERG1 Potassium Channel
por: Grilo, Liliana Sintra, et al.
Publicado: (2010)

Long-Chain Acylcarnitines Regulate the hERG Channel
por: Ferro, Fabio, et al.
Publicado: (2012)

hERG channel function: beyond long QT
por: Babcock, Joseph J, et al.
Publicado: (2013)

Towards a complete structure of the hERG channel
por: Schmidtke, Peter, et al.
Publicado: (2013)

Ion Conduction through the hERG Potassium Channel
por: Ceccarini, Luisa, et al.
Publicado: (2012)

Lipid regulation of hERG1 channel function
por: Miranda, Williams E., et al.
Publicado: (2021)

Idiosyncratic Gating of HERG-like K(+) Channels in Microglia
por: Pennefather, Peter S., et al.
Publicado: (1998)

hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling
por: Wynia-Smith, Sarah L., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_harg9v9pudfe9kvlib7c42orro