Trafficking of High Avidity HER-2/neu-Specific T Cells into HER-2/neu-Expressing Tumors after Depletion of Effector/Memory-Like Regulatory T Cells

BACKGROUND: Cancer vaccines are designed to activate and enhance cancer-antigen-targeted T cells that are suppressed through multiple mechanisms of immune tolerance in cancer-bearing hosts. T regulatory cell (Treg) suppression of tumor-specific T cells is one barrier to effective immunization. A sec...

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Detalles Bibliográficos
Autores principales: Weiss, Vivian L., Lee, Timothy H., Song, Hong, Kouo, Theodore S., Black, Chelsea M., Sgouros, George, Jaffee, Elizabeth M., Armstrong, Todd D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281086/
https://www.ncbi.nlm.nih.gov/pubmed/22359647
http://dx.doi.org/10.1371/journal.pone.0031962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281086/
https://www.ncbi.nlm.nih.gov/pubmed/22359647
http://dx.doi.org/10.1371/journal.pone.0031962

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