Novel Information on the Epitope of an Inverse Agonist Monoclonal Antibody Provides Insight into the Structure of the TSH Receptor

The TSH receptor (TSHR) comprises an extracellular leucine-rich domain (LRD) linked by a hinge region to the transmembrane domain (TMD). Insight into the orientation of these components to each other is required for understanding how ligands activate the receptor. We previously identified residue E2...

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Detalles Bibliográficos
Autores principales: Chen, Chun-Rong, Salazar, Larry M., McLachlan, Sandra M., Rapoport, Basil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281106/
https://www.ncbi.nlm.nih.gov/pubmed/22359649
http://dx.doi.org/10.1371/journal.pone.0031973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281106/
https://www.ncbi.nlm.nih.gov/pubmed/22359649
http://dx.doi.org/10.1371/journal.pone.0031973

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