Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts

BACKGROUND: Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo contain an unknown mix of mouse and human cells. Evaluation of drug activity can be confounded by samples containing large amounts of contaminating mouse tissue. We have developed a real-time quantitative p...

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Detalles Bibliográficos
Autores principales: Alcoser, Sergio Y, Kimmel, David J, Borgel, Suzanne D, Carter, John P, Dougherty, Kelly M, Hollingshead, Melinda G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281124/
https://www.ncbi.nlm.nih.gov/pubmed/22176647
http://dx.doi.org/10.1186/1472-6750-11-124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281124/
https://www.ncbi.nlm.nih.gov/pubmed/22176647
http://dx.doi.org/10.1186/1472-6750-11-124

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