A Medicinal Herb Scutellaria lateriflora Inhibits PrP Replication in vitro and Delays the Onset of Prion Disease in Mice

Transmissible spongiform encephalopathies (TSE) are characterized by the misfolding of the host encoded prion protein (PrP(C)) into a pathogenic isoform (PrP(Sc)) which leads to the accumulation of β-sheet-rich fibrils and subsequent loss of neurons and synaptic functions. Although many compounds ha...

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Detalles Bibliográficos
Autores principales: Eiden, Martin, Leidel, Fabienne, Strohmeier, Barbara, Fast, Christine, Groschup, Martin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281244/
https://www.ncbi.nlm.nih.gov/pubmed/22363300
http://dx.doi.org/10.3389/fpsyt.2012.00009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281244/
https://www.ncbi.nlm.nih.gov/pubmed/22363300
http://dx.doi.org/10.3389/fpsyt.2012.00009

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