Cargando…

STAT5 is a potent negative regulator of T(FH) cell differentiation

Follicular helper T cells (T(FH) cells) constitute the CD4(+) T cell subset that is specialized to provide help to germinal center (GC) B cells and, consequently, mediate the development of long-lived humoral immunity. T(FH) cell differentiation is driven by the transcription factor Bcl6, and recent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnston, Robert J., Choi, Youn Soo, Diamond, Jeffrey A., Yang, Jessica A., Crotty, Shane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281266/ https://www.ncbi.nlm.nih.gov/pubmed/22271576 http://dx.doi.org/10.1084/jem.20111174

Ejemplares similares

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
por: Villarino, Alejandro V., et al.
Publicado: (2007)

Activin A programs human T(FH) cell differentiation
por: Locci, Michela, et al.
Publicado: (2016)

Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4
por: Chikuma, Shunsuke, et al.
Publicado: (2003)

Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum
por: Kawakami, Yuko, et al.
Publicado: (2009)

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1
por: Xi, Hongkang, et al.
Publicado: (2010)

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
por: Pilati, Camilla, et al.
Publicado: (2011)

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function
por: Wilson, Robert P., et al.
Publicado: (2015)

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
por: Serhan, Charles N., et al.
Publicado: (2009)

Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection
por: Milner, J. Justin, et al.
Publicado: (2021)

Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation
por: Ding, Zhaoqing, et al.
Publicado: (2014)

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators
por: Flierl, Ulrike, et al.
Publicado: (2015)

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
por: Ma, Cindy S., et al.
Publicado: (2008)

Synthetic Lipoteichoic Acid from Staphylococcus aureus Is a Potent Stimulus of Cytokine Release
por: Morath, Siegfried, et al.
Publicado: (2002)

Langerhans cells are negative regulators of the anti-Leishmania response
por: Kautz-Neu, Kordula, et al.
Publicado: (2011)

Autocrine Secretion of Interferon γ Negatively Regulates Homing of Immature B Cells
por: Flaishon, Liat, et al.
Publicado: (2000)

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation
por: Erman, Batu, et al.
Publicado: (2004)

Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling
por: Shinohara, Hisaaki, et al.
Publicado: (2005)

Thrombospondin 1 Is an Autocrine Negative Regulator of Human Dendritic Cell Activation
por: Doyen, Virginie, et al.
Publicado: (2003)

The Succinated Proteome of FH-Mutant Tumours
por: Yang, Ming, et al.
Publicado: (2014)

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
por: Pickert, Geethanjali, et al.
Publicado: (2009)

Sialic Acid Binding Domains of CD22 Are Required For Negative Regulation of B Cell Receptor Signaling
por: Jin, Lei, et al.
Publicado: (2002)

A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8(+) T cell tolerance
por: Warshauer, Jeremy T., et al.
Publicado: (2021)

Immunotherapy of Cytotoxic T Cell–resistant Tumors by T Helper 2 Cells: An Eotaxin and STAT6-dependent Process
por: Mattes, Joerg, et al.
Publicado: (2003)

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway
por: Wang, Lin, et al.
Publicado: (2009)

Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
por: Allakhverdi, Zoulfia, et al.
Publicado: (2007)

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
por: Todd, Derrick J., et al.
Publicado: (2009)

Differential Induction of Apoptosis by Fas–Fas Ligand Interactions in Human Monocytes and Macrophages
por: Kiener, Peter A., et al.
Publicado: (1997)

Signal Transducer and Activator of Transcription (Stat)-Induced Stat Inhibitor 1 (Ssi-1)/Suppressor of Cytokine Signaling 1 (Socs1) Inhibits Insulin Signal Transduction Pathway through Modulating Insulin Receptor Substrate 1 (Irs-1) Phosphorylation
por: Kawazoe, Yoshinori, et al.
Publicado: (2001)

A Signal Transducer and Activator of Transcription (Stat)4-independent Pathway for the Development of T Helper Type 1 Cells
por: Kaplan, Mark H., et al.
Publicado: (1998)

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells
por: de Beaucoudrey, Ludovic, et al.
Publicado: (2008)

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice
por: Akimoto, Toshihiko, et al.
Publicado: (1998)

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells
por: Kaiser, Frank, et al.
Publicado: (2009)

IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2
por: Hale, Malika, et al.
Publicado: (2022)

Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy
por: Gruber, Conor, et al.
Publicado: (2020)

miR-181b negatively regulates activation-induced cytidine deaminase in B cells
por: de Yébenes, Virginia G., et al.
Publicado: (2008)

IL-31–IL-31R interactions negatively regulate type 2 inflammation in the lung
por: Perrigoue, Jacqueline G., et al.
Publicado: (2007)

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals
por: Nishizumi, Hirofumi, et al.
Publicado: (1998)

Transcriptional profiling identifies caspase-1 as a T cell–intrinsic regulator of Th17 differentiation
por: Gao, Yajing, et al.
Publicado: (2020)

Arkadia-SKI/SnoN signaling differentially regulates TGF-β–induced iTreg and Th17 cell differentiation
por: Xu, Hao, et al.
Publicado: (2021)

Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis
por: Kim, Nacksung, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_jfp7muq75o3cfqf7fg56c8a2ju