Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells

Somatic mutation of ten-eleven translocation 2 (TET2) gene is frequently found in human myeloid malignancies. Recent reports showed that loss of Tet2 led to pleiotropic hematopoietic abnormalities including increased competitive repopulating capacity of bone marrow (BM) HSCs and myeloid transformati...

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Detalles Bibliográficos
Autores principales: Kunimoto, Hiroyoshi, Fukuchi, Yumi, Sakurai, Masatoshi, Sadahira, Ken, Ikeda, Yasuo, Okamoto, Shinichiro, Nakajima, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281275/
https://www.ncbi.nlm.nih.gov/pubmed/22355785
http://dx.doi.org/10.1038/srep00273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281275/
https://www.ncbi.nlm.nih.gov/pubmed/22355785
http://dx.doi.org/10.1038/srep00273

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