Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms

No current therapies target the underlying cellular pathologies of age-related neurodegenerative diseases. Model organisms provide a platform for discovering compounds that protect against the toxic, misfolded proteins that initiate these diseases. One such protein, TDP-43, is implicated in multiple...

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Detalles Bibliográficos
Autores principales: Tardiff, Daniel F., Tucci, Michelle L., Caldwell, Kim A., Caldwell, Guy A., Lindquist, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281691/
https://www.ncbi.nlm.nih.gov/pubmed/22147697
http://dx.doi.org/10.1074/jbc.M111.308668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281691/
https://www.ncbi.nlm.nih.gov/pubmed/22147697
http://dx.doi.org/10.1074/jbc.M111.308668

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