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Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms
No current therapies target the underlying cellular pathologies of age-related neurodegenerative diseases. Model organisms provide a platform for discovering compounds that protect against the toxic, misfolded proteins that initiate these diseases. One such protein, TDP-43, is implicated in multiple...
Autores principales: | Tardiff, Daniel F., Tucci, Michelle L., Caldwell, Kim A., Caldwell, Guy A., Lindquist, Susan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281691/ https://www.ncbi.nlm.nih.gov/pubmed/22147697 http://dx.doi.org/10.1074/jbc.M111.308668 |
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