Reconsidering Association Testing Methods Using Single-Variant Test Statistics as Alternatives to Pooling Tests for Sequence Data with Rare Variants

Association tests that pool minor alleles into a measure of burden at a locus have been proposed for case-control studies using sequence data containing rare variants. However, such pooling tests are not robust to the inclusion of neutral and protective variants, which can mask the association signa...

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Detalles Bibliográficos
Autores principales: Kinnamon, Daniel D., Hershberger, Ray E., Martin, Eden R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281828/
https://www.ncbi.nlm.nih.gov/pubmed/22363423
http://dx.doi.org/10.1371/journal.pone.0030238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281828/
https://www.ncbi.nlm.nih.gov/pubmed/22363423
http://dx.doi.org/10.1371/journal.pone.0030238

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