Transcriptional Silencing of the Wnt-Antagonist DKK1 by Promoter Methylation Is Associated with Enhanced Wnt Signaling in Advanced Multiple Myeloma

The Wnt/β-catenin pathway plays a crucial role in the pathogenesis of various human cancers. In multiple myeloma (MM), aberrant auto-and/or paracrine activation of canonical Wnt signaling promotes proliferation and dissemination, while overexpression of the Wnt inhibitor Dickkopf1 (DKK1) by MM cells...

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Detalles Bibliográficos
Autores principales: Kocemba, Kinga A., Groen, Richard W. J., van Andel, Harmen, Kersten, Marie José, Mahtouk, Karène, Spaargaren, Marcel, Pals, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281831/
https://www.ncbi.nlm.nih.gov/pubmed/22363428
http://dx.doi.org/10.1371/journal.pone.0030359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281831/
https://www.ncbi.nlm.nih.gov/pubmed/22363428
http://dx.doi.org/10.1371/journal.pone.0030359

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