Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism

YAC128 Huntington's disease (HD) transgenic mice accumulate less manganese (Mn) in the striatum relative to wild-type (WT) littermates. We hypothesized that Mn and mutant Huntingtin (HTT) would exhibit gene-environment interactions at the level of neurochemistry and neuronal morphology. Twelve-...

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Detalles Bibliográficos
Autores principales: Madison, Jennifer L., Wegrzynowicz, Michal, Aschner, Michael, Bowman, Aaron B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281892/
https://www.ncbi.nlm.nih.gov/pubmed/22363539
http://dx.doi.org/10.1371/journal.pone.0031024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281892/
https://www.ncbi.nlm.nih.gov/pubmed/22363539
http://dx.doi.org/10.1371/journal.pone.0031024

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