Cargando…

Geminin overexpression induces mammary tumors via suppressing cytokinesis

Aneuploidy plays an important role in the development of cancer. Here, we uncovered an oncogenic role for geminin in mitotic cells. In addition to chromatin, tyrosine phosphorylated geminin also localizes to centrosome, spindle, cleavage furrow and midbody during mitosis. Geminin binding to Aurora B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blanchard, Zannel, Malik, Rohit, Mullins, Nicole, Maric, Christine, Luk, Hugh, Horio, David, Hernandez, Brenda, Killeen, Jeffrey, ElShamy, Wael M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2011
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282064/ https://www.ncbi.nlm.nih.gov/pubmed/22184288

Ejemplares similares

Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells
por: Gardner, Lauren, et al.
Publicado: (2011)

Geminin Overexpression Promotes Imatinib Sensitive Breast Cancer: A Novel Treatment Approach for Aggressive Breast Cancers, Including a Subset of Triple Negative
por: Blanchard, Zannel, et al.
Publicado: (2014)

BRCA1/p220 loss triggers BRCA1-IRIS overexpression via mRNA stabilization in breast cancer cells
por: Shimizu, Yoshiko, et al.
Publicado: (2012)

Targeting AXL and RAGE to prevent geminin overexpression-induced triple-negative breast cancer metastasis
por: Ryan, Daniel, et al.
Publicado: (2019)

BRCA1-IRIS Overexpression Promotes Formation of Aggressive Breast Cancers
por: Shimizu, Yoshiko, et al.
Publicado: (2012)

Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers
por: Ananthula, Suryatheja, et al.
Publicado: (2016)

BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers
por: Blanchard, Zannel, et al.
Publicado: (2015)

Spotlight on Geminin
por: DePamphilis, Melvin L
Publicado: (2011)

Geminin halts DNA synthesis
por: LeBrasseur, Nicole
Publicado: (2004)

The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells
por: Ryan, Daniel, et al.
Publicado: (2019)

Geminin Is Required for the Maintenance of Pluripotency
por: Tabrizi, Golnaz A., et al.
Publicado: (2013)

The role of BRCA1-IRIS in ovarian cancer formation, drug resistance and progression
por: ElShamy, Wael M.
Publicado: (2016)

A niche that triggers aggressiveness within BRCA1-IRIS overexpressing triple negative tumors is supported by reciprocal interactions with the microenvironment
por: Ryan, Daniel, et al.
Publicado: (2017)

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing
por: Caillat, Christophe, et al.
Publicado: (2013)

Overexpression of UHRF1 promoted the proliferation of vascular smooth cells via the regulation of Geminin protein levels
por: Chen, Xia, et al.
Publicado: (2019)

An Inactive Geminin Mutant That Binds Cdt1
por: Suchyta, Marissa, et al.
Publicado: (2015)

Correction: A niche that triggers aggressiveness within BRCA1-IRIS overexpressing triple negative tumors is supported by reciprocal interactions with the microenvironment
por: Ryan, Daniel, et al.
Publicado: (2017)

Preferential Re-Replication of Drosophila Heterochromatin in the Absence of Geminin
por: Ding, Queying, et al.
Publicado: (2010)

Overexpression of Cell Cycle Progression Inhibitor Geminin is Associated with Tumor Stem-Like Phenotype of Triple-Negative Breast Cancer
por: Di Bonito, Maurizio, et al.
Publicado: (2012)

Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors?
por: ElShamy, Wael M., et al.
Publicado: (2016)

Loss of Geminin induces rereplication in the presence of functional p53
por: Melixetian, Marina, et al.
Publicado: (2004)

Emerging Role of Geminin as a Prognostic Marker in Systemic Malignancies
por: Kapoor, Shailendra
Publicado: (2012)

Transcription of the Geminin gene is regulated by a negative-feedback loop
por: Ohno, Yoshinori, et al.
Publicado: (2014)

Terminal phase of cytokinesis in D-98S cells
por: Mullins, J, et al.
Publicado: (1977)

Geminin Is Required for Zygotic Gene Expression at the Xenopus Mid-Blastula Transition
por: Kerns, Sarah L., et al.
Publicado: (2012)

Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating Geminin
por: Ohno, Yoshinori, et al.
Publicado: (2016)

Geminin Orchestrates Somite Formation by Regulating Fgf8 and Notch Signaling
por: Huang, Wei, et al.
Publicado: (2018)

Secretion for cytokinesis
por: LeBrasseur, Nicole
Publicado: (2005)

The UPR for cytokinesis
por: LeBrasseur, Nicole
Publicado: (2007)

TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation
por: Pitulescu, Mara E, et al.
Publicado: (2009)

Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication
por: Lu, Fei, et al.
Publicado: (2009)

Geminin Inhibits a Late Step in the Formation of Human Pre-replicative Complexes
por: Wu, Min, et al.
Publicado: (2014)

Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility
por: Ma, Xue-Shan, et al.
Publicado: (2016)

SIX3 and SIX6 interact with GEMININ via C-terminal regions
por: Turcu, Diana C., et al.
Publicado: (2019)

Bundle up for cytokinesis
por: LeBrasseur, Nicole
Publicado: (2002)

A time for cytokinesis
por: LeBrasseur, Nicole
Publicado: (2002)

ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
por: Najnin, Rifat Ara, et al.
Publicado: (2023)

BRCA1-IRIS overexpression promotes and maintains the tumor initiating phenotype: implications for triple negative breast cancer early lesions
por: Sinha, Abhilasha, et al.
Publicado: (2016)

Geminin-Deficient Neural Stem Cells Exhibit Normal Cell Division and Normal Neurogenesis
por: Schultz, Kathryn M., et al.
Publicado: (2011)

Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility
por: YUAN, Yue, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o3kj9m6nifb7l9goo7in6ln1j4