M cell-depletion blocks oral prion disease pathogenesis

Many prion diseases are orally acquired. Our data show that after oral exposure, early prion replication upon follicular dendritic cells (FDC) in Peyer's patches is obligatory for the efficient spread of disease to the brain (termed neuroinvasion). For prions to replicate on FDC within Peyer�...

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Detalles Bibliográficos
Autores principales: Donaldson, D S, Kobayashi, A, Ohno, H, Yagita, H, Williams, I R, Mabbott, N A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282432/
https://www.ncbi.nlm.nih.gov/pubmed/22294048
http://dx.doi.org/10.1038/mi.2011.68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282432/
https://www.ncbi.nlm.nih.gov/pubmed/22294048
http://dx.doi.org/10.1038/mi.2011.68

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