Biscarbamate cross-linked polyethylenimine derivative with low molecular weight, low cytotoxicity, and high efficiency for gene delivery

Polyethylenimine (PEI), especially PEI 25 kDa, has been widely studied for delivery of nucleic acid drugs both in vitro and in vivo. However, it lacks degradable linkages and is too toxic for therapeutic applications. Hence, low-molecular-weight PEI has been explored as an alternative to PEI 25 kDa....

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Detalles Bibliográficos
Autores principales: Wang, Yu-Qiang, Su, Jing, Wu, Fei, Lu, Ping, Yuan, Li-Fen, Yuan, Wei-En, Sheng, Jing, Jin, Tuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282609/
https://www.ncbi.nlm.nih.gov/pubmed/22359448
http://dx.doi.org/10.2147/IJN.S27849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282609/
https://www.ncbi.nlm.nih.gov/pubmed/22359448
http://dx.doi.org/10.2147/IJN.S27849

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