Lysine Residue at Position 22 of the AID Protein Regulates Its Class Switch Activity

BACKGROUND: Activation induced deaminase (AID) mediates class switch recombination and somatic hypermutation of immunoglobulin (Ig) genes in germinal centre B cells. In order to regulate its specific activity and as a means to keep off-target mutations low, several mechanisms have evolved, including...

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Detalles Bibliográficos
Autores principales: Geisberger, Roland, Huemer, Michael, Gassner, Franz J., Zaborsky, Nadja, Egle, Alexander, Greil, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282692/
https://www.ncbi.nlm.nih.gov/pubmed/22363466
http://dx.doi.org/10.1371/journal.pone.0030667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282692/
https://www.ncbi.nlm.nih.gov/pubmed/22363466
http://dx.doi.org/10.1371/journal.pone.0030667

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