Cargando…

Novel Protein Kinase Signaling Systems Regulating Lifespan Identified by Small Molecule Library Screening Using Drosophila

Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies. Herein we describe screening of a library of small molecule inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spindler, Stephen R., Li, Rui, Dhahbi, Joseph M., Yamakawa, Amy, Sauer, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282711/ https://www.ncbi.nlm.nih.gov/pubmed/22363408 http://dx.doi.org/10.1371/journal.pone.0029782

Ejemplares similares

Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation
por: Spindler, Stephen R., et al.
Publicado: (2012)

Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice
por: Spindler, Stephen R., et al.
Publicado: (2015)

MicroRNAs Circulate in the Hemolymph of Drosophila and Accumulate Relative to Tissue microRNAs in an Age-Dependent Manner
por: Dhahbi, Joseph M., et al.
Publicado: (2016)

Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction
por: Dhahbi, Joseph M, et al.
Publicado: (2013)

A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster
por: Nakayama, Minoru, et al.
Publicado: (2014)

Deep Sequencing of Serum Small RNAs Identifies Patterns of 5′ tRNA Half and YRNA Fragment Expression Associated with Breast Cancer
por: Dhahbi, Joseph M, et al.
Publicado: (2014)

Screening a small molecule library to identify inhibitors of NF-κB inducing kinase and pro-labor genes in human placenta
por: Wang, Bingbing, et al.
Publicado: (2018)

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction
por: Dhahbi, Joseph M, et al.
Publicado: (2013)

A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs
por: Cao, Jianzhong, et al.
Publicado: (2015)

Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target
por: Gasque, Gabriel, et al.
Publicado: (2013)

A mini-screen to identify the role of microRNAs in the Drosophila Insulin-Producing cells regulating lifespan
por: Fernandes, Jervis, et al.
Publicado: (2022)

Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2
por: Li, Shufen, et al.
Publicado: (2021)

Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA
por: Chen, Qiuxia, et al.
Publicado: (2022)

High-Throughput Screening of Small Molecule Libraries using SAMDI Mass Spectrometry
por: Gurard-Levin, Zachary A., et al.
Publicado: (2011)

Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
por: Wu, Chun-Yi, et al.
Publicado: (2016)

Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis
por: Morel, Marion, et al.
Publicado: (2014)

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans’ Lifespan
por: Zhang, Peichuan, et al.
Publicado: (2019)

5′ tRNA Halves: The Next Generation of Immune Signaling Molecules
por: Dhahbi, Joseph Mohsen
Publicado: (2015)

Novel Anti-Campylobacter Compounds Identified Using High Throughput Screening of a Pre-selected Enriched Small Molecules Library
por: Kumar, Anand, et al.
Publicado: (2016)

Sleep, aging, and lifespan in Drosophila
por: Bushey, Daniel, et al.
Publicado: (2010)

A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation
por: Li, Zhonghan, et al.
Publicado: (2012)

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila
por: Biteau, Benoît, et al.
Publicado: (2010)

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction
por: Schimmel, Katharina, et al.
Publicado: (2020)

Light-assisted small molecule screening against protein kinases
por: Inglés-Prieto, Álvaro, et al.
Publicado: (2015)

Screening of the small molecule library of Meinox enables the identification of anticancer compounds in pathologically distinct cancers
por: MAMMADOVA, Aynura, et al.
Publicado: (2021)

Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila
por: Soulé, Stéphanie, et al.
Publicado: (2020)

Sirt6 regulates lifespan in Drosophila melanogaster
por: Taylor, Jackson R., et al.
Publicado: (2022)

Antimicrobial peptides extend lifespan in Drosophila
por: Loch, Gerrit, et al.
Publicado: (2017)

Caspar SUMOylation regulates Drosophila lifespan
por: Kaduskar, Bhagyashree, et al.
Publicado: (2020)

Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity
por: Sen, Edanur, et al.
Publicado: (2021)

Identifying C. elegans lifespan mutants by screening for early-onset protein aggregation
por: Midkiff, Daniel F., et al.
Publicado: (2022)

Small Molecule Library Synthesis Using Segmented Flow
por: Thompson, Christina M., et al.
Publicado: (2011)

A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation
por: Rylee, Johnathan, et al.
Publicado: (2022)

Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster
por: Taylor, Jackson, et al.
Publicado: (2020)

In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors
por: Kleiner, Ralph E., et al.
Publicado: (2010)

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila
por: Weigelt, Carina Marianne, et al.
Publicado: (2020)

Forward genetic screens identify mechanisms of resistance to small molecule lactate dehydrogenase inhibitors
por: Frank, Anderson R, et al.
Publicado: (2023)

Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries
por: Fritzell, Kajsa, et al.
Publicado: (2019)

Gypsum-DL: an open-source program for preparing small-molecule libraries for structure-based virtual screening
por: Ropp, Patrick J., et al.
Publicado: (2019)

Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries
por: Ronzetti, Michael H., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8t79ba58m1t612t5pgsnra1bq0