miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets

Changes in cellular cholesterol affect insulin secretion, and β-cell–specific deletion or loss-of-function mutations in the cholesterol efflux transporter ATP-binding cassette transporter A1 (ABCA1) result in impaired glucose tolerance and β-cell dysfunction. Upregulation of ABCA1 expression may the...

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Detalles Bibliográficos
Autores principales: Wijesekara, Nadeeja, Zhang, Lin-hua, Kang, Martin H., Abraham, Thomas, Bhattacharjee, Alpana, Warnock, Garth L., Verchere, C. Bruce, Hayden, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282802/
https://www.ncbi.nlm.nih.gov/pubmed/22315319
http://dx.doi.org/10.2337/db11-0944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282802/
https://www.ncbi.nlm.nih.gov/pubmed/22315319
http://dx.doi.org/10.2337/db11-0944

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