Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure

Type 2 diabetes ultimately results from pancreatic β-cell failure. Abnormally elevated intracellular regeneration of glucocorticoids by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in fat or liver may underlie pathophysiological aspects of the metabolic syndrome. Elevated 11β-HSD1 i...

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Detalles Bibliográficos
Autores principales: Turban, Sophie, Liu, Xiaoxia, Ramage, Lynne, Webster, Scott P., Walker, Brian R., Dunbar, Donald R., Mullins, John J., Seckl, Jonathan R., Morton, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282808/
https://www.ncbi.nlm.nih.gov/pubmed/22315313
http://dx.doi.org/10.2337/db11-1054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282808/
https://www.ncbi.nlm.nih.gov/pubmed/22315313
http://dx.doi.org/10.2337/db11-1054

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