Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

BACKGROUND: Microglia are considered a major target for modulating neuroinflammatory and neurodegenerative disease processes. Upon activation, microglia secrete inflammatory mediators that contribute to the resolution or to further enhancement of damage in the central nervous system (CNS). Therefore...

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Detalles Bibliográficos
Autores principales: de Oliveira, Antonio CP, Candelario-Jalil, Eduardo, Langbein, Julia, Wendeburg, Lena, Bhatia, Harsharan S, Schlachetzki, Johannes CM, Biber, Knut, Fiebich, Bernd L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283507/
https://www.ncbi.nlm.nih.gov/pubmed/22214188
http://dx.doi.org/10.1186/1742-2094-9-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283507/
https://www.ncbi.nlm.nih.gov/pubmed/22214188
http://dx.doi.org/10.1186/1742-2094-9-2

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