Cargando…

Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias

BACKGROUND: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clarke, Robert, Bennett, Derrick A., Parish, Sarah, Verhoef, Petra, Dötsch-Klerk, Mariska, Lathrop, Mark, Xu, Peng, Nordestgaard, Børge G., Holm, Hilma, Hopewell, Jemma C., Saleheen, Danish, Tanaka, Toshihiro, Anand, Sonia S., Chambers, John C., Kleber, Marcus E., Ouwehand, Willem H., Yamada, Yoshiji, Elbers, Clara, Peters, Bas, Stewart, Alexandre F. R., Reilly, Muredach M., Thorand, Barbara, Yusuf, Salim, Engert, James C., Assimes, Themistocles L., Kooner, Jaspal, Danesh, John, Watkins, Hugh, Samani, Nilesh J., Collins, Rory, Peto, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283559/ https://www.ncbi.nlm.nih.gov/pubmed/22363213 http://dx.doi.org/10.1371/journal.pmed.1001177

Ejemplares similares

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study
por: Hopewell, Jemma C., et al.
Publicado: (2013)

The Potential of Condiments, Seasonings, and Bouillon Cubes to Deliver Essential Micronutrients in Asia: Scenario Analyses of Iodine and Iron Fortification
por: Eilander, Ans, et al.
Publicado: (2023)

Dietary Impact of Adding Potassium Chloride to Foods as a Sodium Reduction Technique
por: van Buren, Leo, et al.
Publicado: (2016)

Modelling of Usual Nutrient Intakes: Potential Impact of the Choices Programme on Nutrient Intakes in Young Dutch Adults
por: Roodenburg, Annet J. C., et al.
Publicado: (2013)

Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study
por: Valdes-Marquez, Elsa, et al.
Publicado: (2019)

Independent risk factors for simvastatin-related myopathy and relevance to different types of muscle symptom
por: Hopewell, Jemma C, et al.
Publicado: (2020)

Improving the Nutrient Quality of Foods and Beverages Using Product Specific Standards for Nutrients to Limit Will Substantially Reduce Mean Population Intakes of Energy, Sodium, Saturated Fat and Sugars towards WHO Guidelines
por: Dötsch-Klerk, Mariska, et al.
Publicado: (2022)

Contribution of lower physical activity levels to higher risk of insulin resistance and associated metabolic disturbances in South Asians compared to Europeans
por: Afaq, Saima, et al.
Publicado: (2019)

The 1316T>C missenses mutation in MTHFR contributes to MTHFR deficiency by targeting MTHFR to proteasome degradation
por: Liu, Xi, et al.
Publicado: (2020)

Modelling health and economic impact of nutrition interventions: a systematic review
por: Dötsch-Klerk, Mariska, et al.
Publicado: (2022)

A Modelling Approach to Estimate the Impact of Sodium Reduction in Soups on Cardiovascular Health in the Netherlands
por: Bruins, Maaike J., et al.
Publicado: (2015)

Accelerated ageing is associated with increased COVID-19 severity and differences across ethnic groups may exist
por: Reeves, Joshua, et al.
Publicado: (2022)

Associations between polygenic risk score and covid-19 susceptibility and severity across ethnic groups: UK Biobank analysis
por: Farooqi, Raabia, et al.
Publicado: (2023)

Comorbidities associated with the severity of COVID-19, and differences across ethnic groups: a UK Biobank cohort study
por: Patel, Rahul, et al.
Publicado: (2023)

The role of lipoprotein (a) in chronic kidney disease
por: Hopewell, Jemma C., et al.
Publicado: (2018)

Potential Effects of Nutrient Profiles on Nutrient Intakes in the Netherlands, Greece, Spain, USA, Israel, China and South-Africa
por: Roodenburg, Annet J. C., et al.
Publicado: (2011)

Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation
por: Chiu, Ming-Huang, et al.
Publicado: (2023)

Novel compound heterozygous mutations of MTHFR Gene in a Chinese family with homocystinuria due to MTHFR deficiency
por: Lu, Yitong, et al.
Publicado: (2022)

MTHFR polymorphisms and breast cancer risk
por: Hosseini, Mojgan, et al.
Publicado: (2011)

A key risk indicator approach to central statistical monitoring in multicentre clinical trials: method development in the context of an ongoing large-scale randomized trial
por: Elsa, Valdés-Márquez, et al.
Publicado: (2011)

Central statistical monitoring in multicentre clinical trials: developing statistical approaches for analysing key risk indicators
por: Valdes-Marquez, Elsa, et al.
Publicado: (2013)

Identifying systematic heterogeneity patterns in genetic association meta-analysis studies
por: Magosi, Lerato E., et al.
Publicado: (2017)

Identifying small-effect genetic associations overlooked by the conventional fixed-effect model in a large-scale meta-analysis of coronary artery disease
por: Magosi, Lerato E, et al.
Publicado: (2019)

Subgroup differences in psychosocial factors relating to coronary heart disease in the UK South Asian population()
por: Williams, Emily D., et al.
Publicado: (2010)

Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
por: Aikens, Rachael C., et al.
Publicado: (2017)

Association of MTHFR Polymorphisms and Chromosomal Abnormalities in Leukemia
por: Sinthuwiwat, Thivaratana, et al.
Publicado: (2012)

MTHFR polymorphisms in primary varicose vein disorder
por: Fernández-Peralta, Antonia M., et al.
Publicado: (2015)

The association between MTHFR polymorphism and cervical cancer
por: Gong, Jiao-Mei, et al.
Publicado: (2018)

A Patient with Combined CADASIL and MTHFR Homozygosity
por: Ibrikji, Sidonie, et al.
Publicado: (2020)

Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes
por: Grace, Christopher, et al.
Publicado: (2021)

Meta-Prediction of MTHFR Gene Polymorphism Mutations and Associated Risk for Colorectal Cancer
por: Shiao, S. P. K., et al.
Publicado: (2016)

BRCA2 Variants and cardiovascular disease in a multi-ethnic study
por: Zbuk, Kevin, et al.
Publicado: (2012)

Independent effects of adiposity measures on risk of atrial fibrillation in men and women: a study of 0.5 million individuals
por: Camm, C Fielder, et al.
Publicado: (2021)

Assessment of Vascular Event Prevention and Cognitive Function Among Older Adults With Preexisting Vascular Disease or Diabetes: A Secondary Analysis of 3 Randomized Clinical Trials
por: Offer, Alison, et al.
Publicado: (2019)

MTHFR C677T, MTHFR A1298C, and OPG A163G Polymorphisms in Mexican Patients with Rheumatoid Arthritis and Osteoporosis
por: Brambila-Tapia, Aniel Jessica Leticia, et al.
Publicado: (2012)

The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency
por: Spellicy, Catherine J., et al.
Publicado: (2013)

Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study
por: Parish, Sarah, et al.
Publicado: (2018)

Human genetic selection on the MTHFR 677C>T polymorphism
por: Mayor-Olea, Álvaro, et al.
Publicado: (2008)

Association of MTHFR gene polymorphisms with breast cancer survival
por: Martin, Damali N, et al.
Publicado: (2006)

Analysis of the MTHFR C677T variant with migraine phenotypes
por: Liu, Annie, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_66kmaib3hudsnmrvvslpv91bm7