Post-Transcriptional Regulation of 5-Lipoxygenase mRNA Expression via Alternative Splicing and Nonsense-Mediated mRNA Decay

5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid. Here, we investigated the regulation of 5-LO mRNA expression by alternative splicing and nonsense-mediated mRNA decay (NMD). In the p...

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Detalles Bibliográficos
Autores principales: Ochs, Meike J., Sorg, Bernd L., Pufahl, Laura, Grez, Manuel, Suess, Beatrix, Steinhilber, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283622/
https://www.ncbi.nlm.nih.gov/pubmed/22363630
http://dx.doi.org/10.1371/journal.pone.0031363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283622/
https://www.ncbi.nlm.nih.gov/pubmed/22363630
http://dx.doi.org/10.1371/journal.pone.0031363

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