Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans

Mutations in the DNA/RNA binding proteins TDP-43 and FUS are associated with Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Intracellular accumulations of wild type TDP-43 and FUS are observed in a growing number of late-onset diseases suggesting that TDP-43 and FUS proteinopat...

Descripción completa

Detalles Bibliográficos
Autores principales: Vaccaro, Alexandra, Tauffenberger, Arnaud, Aggad, Dina, Rouleau, Guy, Drapeau, Pierre, Parker, J. Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283630/
https://www.ncbi.nlm.nih.gov/pubmed/22363618
http://dx.doi.org/10.1371/journal.pone.0031321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283630/
https://www.ncbi.nlm.nih.gov/pubmed/22363618
http://dx.doi.org/10.1371/journal.pone.0031321

Ejemplares similares