Cargando…

Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans

Mutations in the DNA/RNA binding proteins TDP-43 and FUS are associated with Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Intracellular accumulations of wild type TDP-43 and FUS are observed in a growing number of late-onset diseases suggesting that TDP-43 and FUS proteinopat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vaccaro, Alexandra, Tauffenberger, Arnaud, Aggad, Dina, Rouleau, Guy, Drapeau, Pierre, Parker, J. Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283630/ https://www.ncbi.nlm.nih.gov/pubmed/22363618 http://dx.doi.org/10.1371/journal.pone.0031321

Ejemplares similares

TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans
por: Vaccaro, Alexandra, et al.
Publicado: (2012)

Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio
por: Vaccaro, Alexandra, et al.
Publicado: (2012)

Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions
por: Ling, Shuo-Chien
Publicado: (2018)

Fragile lifespan expansion by dietary mitohormesis in C. elegans
por: Tauffenberger, Arnaud, et al.
Publicado: (2016)

Neuropathological potential of FUS and TDP-43 in flies
Publicado: (2011)

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions
por: Farrawell, Natalie E., et al.
Publicado: (2015)

Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage
por: Kawaguchi, Tetsuya, et al.
Publicado: (2019)

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes
por: Sleigh, James N., et al.
Publicado: (2020)

Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration
por: Gendron, Tania F., et al.
Publicado: (2011)

Sustained Expression of TDP-43 and FUS in Motor Neurons in Rodent's Lifetime
por: Huang, Cao, et al.
Publicado: (2010)

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS
por: Farrawell, Natalie E., et al.
Publicado: (2020)

Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines
por: Lissouba, Alexandra, et al.
Publicado: (2018)

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice
por: Yang, Chunxing, et al.
Publicado: (2022)

Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
por: Koga, Shunsuke, et al.
Publicado: (2023)

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
por: Xie, Manling, et al.
Publicado: (2021)

Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration
por: Seelaar, Harro, et al.
Publicado: (2009)

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
por: Herdewyn, Sarah, et al.
Publicado: (2014)

TDP-43 and ER Stress in Neurodegeneration: Friends or Foes?
por: de Mena, Lorena, et al.
Publicado: (2021)

α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy
por: Wong, Shi Quan, et al.
Publicado: (2018)

An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration
por: Flores, Brittany N., et al.
Publicado: (2019)

Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans
por: Tauffenberger, Arnaud, et al.
Publicado: (2014)

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain
por: Harley, Jasmine, et al.
Publicado: (2021)

Publisher Correction to: Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
por: Koga, Shunsuke, et al.
Publicado: (2023)

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
por: Urwin, Hazel, et al.
Publicado: (2010)

Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
por: Ederle, Helena, et al.
Publicado: (2018)

Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases
por: Carey, Jenny L., et al.
Publicado: (2022)

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity
por: Tariq, Amber, et al.
Publicado: (2019)

Does a loss of TDP-43 function cause neurodegeneration?
por: Xu, Zuo-Shang
Publicado: (2012)

The Role of TDP-43 in Military-Relevant TBI and Chronic Neurodegeneration
por: Heyburn, Lanier, et al.
Publicado: (2019)

Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis
por: Pokrishevsky, Edward, et al.
Publicado: (2012)

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
por: Aulas, Anaïs, et al.
Publicado: (2012)

Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations
por: Finelli, Mattéa J., et al.
Publicado: (2015)

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies
por: Koopman, Mandy, et al.
Publicado: (2023)

Divergent Phenotypes in Mutant TDP-43 Transgenic Mice Highlight Potential Confounds in TDP-43 Transgenic Modeling
por: D’Alton, Simon, et al.
Publicado: (2014)

TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander
por: Banks, Gareth T., et al.
Publicado: (2008)

To Be or Not To Be…Toxic—Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration?
por: Loganathan, Suvithanandhini, et al.
Publicado: (2020)

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
por: Kasu, Yasar Arfat T., et al.
Publicado: (2022)

RNA targets of TDP-43: Which one is more important in neurodegeneration?
por: Halim, Dilara, et al.
Publicado: (2022)

Mechanisms underlying TDP-43 pathology and neurodegeneration: An updated Mini-Review
por: Nilaver, Benjamin I., et al.
Publicado: (2023)

FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis
por: Kabashi, Edor, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_uvbnk7nobq608upfq4j72pp28n