Zidovudine (AZT) Monotherapy Selects for the A360V Mutation in the Connection Domain of HIV-1 Reverse Transcriptase

BACKGROUND: We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT) which, together with the thymidine analog mutations D67N, K70R and T215F, confer greater than 100-fold AZT...

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Detalles Bibliográficos
Autores principales: Brehm, Jessica H., Scott, Yanille, Koontz, Dianna L., Perry, Steven, Hammer, Scott, Katzenstein, David, Mellors, John W., Sluis-Cremer, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283647/
https://www.ncbi.nlm.nih.gov/pubmed/22363673
http://dx.doi.org/10.1371/journal.pone.0031558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283647/
https://www.ncbi.nlm.nih.gov/pubmed/22363673
http://dx.doi.org/10.1371/journal.pone.0031558

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