The Presence of the Iron-Sulfur Motif Is Important for the Conformational Stability of the Antiviral Protein, Viperin

Viperin, an antiviral protein, has been shown to contain a CX(3)CX(2)C motif, which is conserved in the radical S-adenosyl-methionine (SAM) enzyme family. A triple mutant which replaces these three cysteines with alanines has been shown to have severe deficiency in antiviral activity. Since the crys...

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Detalles Bibliográficos
Autores principales: Haldar, Shubhasis, Paul, Simantasarani, Joshi, Nidhi, Dasgupta, Anindya, Chattopadhyay, Krishnananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283665/
https://www.ncbi.nlm.nih.gov/pubmed/22363738
http://dx.doi.org/10.1371/journal.pone.0031797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283665/
https://www.ncbi.nlm.nih.gov/pubmed/22363738
http://dx.doi.org/10.1371/journal.pone.0031797

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