Low-Resolution Molecular Models Reveal the Oligomeric State of the PPAR and the Conformational Organization of Its Domains in Solution

The peroxisome proliferator-activated receptors (PPARs) regulate genes involved in lipid and carbohydrate metabolism, and are targets of drugs approved for human use. Whereas the crystallographic structure of the complex of full length PPARγ and RXRα is known, structural alterations induced by heter...

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Detalles Bibliográficos
Autores principales: Bernardes, Amanda, Batista, Fernanda A. H., de Oliveira Neto, Mario, Figueira, Ana Carolina M., Webb, Paul, Saidemberg, Daniel, Palma, Mario S., Polikarpov, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283691/
https://www.ncbi.nlm.nih.gov/pubmed/22363753
http://dx.doi.org/10.1371/journal.pone.0031852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283691/
https://www.ncbi.nlm.nih.gov/pubmed/22363753
http://dx.doi.org/10.1371/journal.pone.0031852

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