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Low-Resolution Molecular Models Reveal the Oligomeric State of the PPAR and the Conformational Organization of Its Domains in Solution
The peroxisome proliferator-activated receptors (PPARs) regulate genes involved in lipid and carbohydrate metabolism, and are targets of drugs approved for human use. Whereas the crystallographic structure of the complex of full length PPARγ and RXRα is known, structural alterations induced by heter...
Autores principales: | Bernardes, Amanda, Batista, Fernanda A. H., de Oliveira Neto, Mario, Figueira, Ana Carolina M., Webb, Paul, Saidemberg, Daniel, Palma, Mario S., Polikarpov, Igor |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283691/ https://www.ncbi.nlm.nih.gov/pubmed/22363753 http://dx.doi.org/10.1371/journal.pone.0031852 |
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