Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass

The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de novo lipogenesis (DNL) seem to be the key points of hepatocyte accumulation of lipids. One key transcription factor in DNL is sterol regulatory element-binding protein (SREBP)-1c. We generated mice with liv...

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Detalles Bibliográficos
Autores principales: Knebel, Birgit, Haas, Jutta, Hartwig, Sonja, Jacob, Sylvia, Köllmer, Cornelia, Nitzgen, Ulrike, Muller–Wieland, Dirk, Kotzka, Jorg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283692/
https://www.ncbi.nlm.nih.gov/pubmed/22363740
http://dx.doi.org/10.1371/journal.pone.0031812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283692/
https://www.ncbi.nlm.nih.gov/pubmed/22363740
http://dx.doi.org/10.1371/journal.pone.0031812

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