The Prevalence and Cost of Unapproved Uses of Top-Selling Orphan Drugs

INTRODUCTION: The Orphan Drug Act encourages drug development for rare conditions. However, some orphan drugs become top sellers for unclear reasons. We sought to evaluate the extent and cost of approved and unapproved uses of orphan drugs with the highest unit sales. METHODS: We assessed prescripti...

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Detalles Bibliográficos
Autores principales: Kesselheim, Aaron S., Myers, Jessica A., Solomon, Daniel H., Winkelmayer, Wolfgang C., Levin, Raisa, Avorn, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283698/
https://www.ncbi.nlm.nih.gov/pubmed/22363762
http://dx.doi.org/10.1371/journal.pone.0031894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283698/
https://www.ncbi.nlm.nih.gov/pubmed/22363762
http://dx.doi.org/10.1371/journal.pone.0031894

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